Since high-rise buildings are prone to collapse under the action of earthquakes, thus seriously affecting people's personal safety, prediction of seismic safety distances of high-rise buildings is very important. A prediction system for seismic safety distance of high-rise buildings, with a basic database as the core, was designed in this study. Basic data of height, width, and structural type of a set of high-rise buildings was collected through a basic information system, and then stored in the seismic damage database system. The seismic hazard model analysis system, based on the basic information of the buildings stored in the database system, first analyzed the seismic hazard, then calculated the safe, protective distance by studying the height of the upper structure of the weak layer under three landing states. Experiments showed that, under the action of artificial seismic waves, a sketch map of safe, protective distances of high-rise buildings in the experimental area was effectively obtained through the prediction system. The safe distance of "flying stone," as well as the distribution and main influence ranges of seismic safe protective distances under three kinds of seismic waves were accurately analyzed. The predictive power of this method was good.