In this study,we performed the seismic vulnerability analysis of reinforced concrete (RC) frame buildings based on nonlinear dynamic time history analysis and ground motion parameters.We used a typical 12-story RC frame structure as the research object.First,we conducted static pushover analysis to identify a weak layer and to determine the capacity parameters of the building.Then,we performed nonlinear dynamic time history analysis to estimate the seismic response of the structure and to analyze the relation between the demand and ground motion parameters.With respect to ground motion parameters,we studied the uncertainty of the structural response and then established peak ground acceleration and vulnerability curves based on the first-mode acceleration response spectrum.By considering the impacts of site conditions on ground motion characteristics,we examined the impact of site conditions on vulnerability.The results show differences in vulnerability curves under different site conditions.Based on ground motion parameters obtained from new-generation seismic zoning maps or seismic safety evaluations,the proposed method can be used to directly estimate damage to a structure following an earthquake,which has significance in seismic performance evaluations and in the prediction of earthquake losses.