In this paper, the GNSS data from Crustal Movement Observation Network of China (CMONOC) were used to analyze the changes of velocity field, principal strain rate field, maximum shear strain rate field, and surface strain field, as well as the changes of active fault slip rate and cross-fault baseline in the northeastern Qinghai-Tibet Plateau from 1998 to 2018 after excluding the effect of co-seismic response and other disturbances. The secondary blocks in the study area were subdivided to obtain the change of strain rate in each secondary block. The trend and dynamic characteristics of crustal movement field in the study area were also obtained. The results show that the thrust movement along the middle and eastern segment of Altyn Tagh fault, the junction of Qilian block and Qaidam block, the junction of Bayankala block and Qiangtang block, the middle section of the southern boundary of Qilian block, the Haiyuan-Liupanshan fault, and the western segment of the northern West Qinling fault, the left-lateral strike-slip movement along the western section of northern boundary of Qilian block and the Zhuanglanghe fault, and the sinistral strike-slip movement along the eastern section of northern boundary of Qilian block and the eastern section of northern edge of West Qinling Mountains all belong to the continuous local strain enhancement movement with a certain degree of crustal deformation. The eastern section of Altyn Tagh fault zone, the middle and western section of East Kunlun fault zone, the northern boundary of Qilian block, the northern section of Zhuanglanghe fault, the southern section of Haiyuan fault, the northern section of Liupanshan fault, and the eastern section of northern edge fault of West Qinling Mountains may be locked, and M_S＞6.0 earthquakes may occur in these areas in the next decade.