Abstract: An MS 6.8 earthquake occurred in Dingri County, Shigatse City, Xizang Province on January 7, 2025, causing extensive damage to buildings and significant casualties. To acquire rapid seismic damage information, building damage features from GF-2 satellite imagery in three representative townships within the high-intensity zones (intensity IX, VIII, and VII) are interpreted, including the Changsuo town, the Cuoguo town, and the Quluo town. A remote-sensing damage index is calculated based on analyzing the influencing factors. The results show that 1,435 buildings in the three towns are damaged to varying degrees, including complete collapse, partial collapse or damage, and essentially intact. Aging brick-timber structures and densely clustered self-built houses exhibited severe collapse, whereas newly constructed buildings demonstrated markedly superior seismic performance. In addition, building damage severity correlated positively with seismic intensity. The highest collapse proportions were observed in the intensity IX zone (Cuoguo town 27.90%, Changsuo town 26.20%), with remote-sensing damage indexes of 0.44 and 0.48, respectively. However, the remote-sensing damage indexes decreased substantially to 0.19 and 0.12 in the seismic intensity VIII and VII zones. Spatially, damaged buildings were concentrated along the Dengmocuo fault zone. A fitting relationship between the remote-sensing damage indexes and the distance from the fault was subsequently established. Additionally, the relationship between the damage ratio and earthquake intensity has been analyzed. The findings can enhance rapid earthquake-damage assessment capabilities and provide critical data support for emergency response and rescue decision-making.