The research works on the crust and upper mantle structure in Jiangsu province and its adjacent areas, that is divided into the southeastern Yangzi block, the southern segment of Tancheng-Lujiang fault zone, the eastern segment of Dabie orogen and the Sulu UHPM block according to geotectonics and research level, are introduced based on the results of different research methods such as deep seismic sounding, earthquake travel time tomography and other geophysical survey. The main characteristics are summarized as following points. The depths of Moho is various from 28 km to 33 km beneath the southeastern Yangzi block with decreasing from weat to east. It exists a high velocity layer in the top of crust of Dabie-Sulu UHPM zone with thickness less than 10 kin. The thickness of crust in Sulu block is in 32-33 km, and is thicker than those in the surrounding area. For Dabie orogen, the depth of crust is about 33 km and changes gently along the direction of the orogen belt, but changes greatly across the belt with the greatest 41 km depth of Moho in some areas. The results of earthquake tomography commonly have low-resolution because of large size of research area. Many works of deep seismic sounding in Dabie-Sulu zone have been done but the work range is too small and survey layer is shallow, so more works on larger area are needed to the deep structure of crust.