The fault-block structures are well developed in the coastal area of Fujian province. The boundary of the area is the Minjiang River and the Jioulong River. The differential movement of fault-blocks since neotectonic period may be divided into three regions, i. e. thenorthern, the southern and the middle. The preparation for 1604 Quanzhou earthquake is considered to be conform to the combinatorial model theory. The middle fault-block is corresponding to its accumulation unit of stress, the northern and southern fault-blocks are corresponding to its adjustment units of stress. They have quite different respectively. The preparation process of the earthquake is divided into several periods, and the patterns of stress effect and analyzed.