In this paper, the effect of radon in hydrofracturing experiments at the experimental area of the Tangkeng village ZK10 well, Nanging county, Fujian province is introduced. Water-radon and soil-radon changes with the increase of pressure. For example, the variable amplitudes of water-radon are 15%, 13.5% and 7.5% in the ZK12 well with the different pressure; variable amplitudes of soil-radon as +219% and +186%, -110% and -197% in the 1° and 4° observation point respectively.