By studying earthquake activity characteristics of M≥5.0 in China mainland （Xinjiang and deep earthquake area in northeast China haven＇t been included） since 2000, it is found that the case for M≥5.0 earthquakes occurring one after another around the sourec area is significant feature of seismicity in certain regions. Based on this characteristic, the medium term prediction can be made for future earthquakes of M≥5.0 in study area.