Several earthquake precursory methods are combined to investigate the future large earthquake potential in the research region.First the Pattern Informatics（PI） method is used to quantify localized changes surrounding the epicenters of large earthquakes and to objectively quantify the anomalous areas（hot spots） of the upcoming events.Then the seismogenic regions of the ensuing large events are delineated by integrating with associated active fault zones.Finally,the earthquake potential in the region is evaluated using 3 other short-to-intermediate-term earthquake prediction methods（Load Unload Response Ratio,State Vector,and Accelerate Moment Release）.In the spatial scale the approach can achieve the gradual approximation to the seismogenic zones;while in the temporal scale,the approach can achieve the natural transition from the long term to the short-to-intermediate-term earthquake forecast.As a retrospective study,the large earthquakes（ML6.5） occurred in western China in last 3 years are examined.The results may suggest that,rather than a single precursory method,the multi-methods combined approach can be a useful tool to provide stronger constraints on forecasts of future large events.