This paper presents geo-electrical research in earthquakes and their forecasting performed prior to and immediately following the Minxian-Zhangxian MS6.6 earthquake and appraises the observation data anomalies in apparent resistivity that appeared at stations in southeastern Gansu and its adjacent areas.The results of the research roughly agree with observation data of the actual principal earthquake and its strong aftershocks.In addition,the observation data anomalies include the anomalous information in apparent resistivity,which is directly associated with the earthquake and the data anomalies in apparent resistivity caused by certain disturbance factors.Therefore,the results have scientific significance in earthquake forecasting and obvious uncertainty;however,the testing is only tentative.Moreover,this paper examines several important factors in geo-electrical observation such as environmental protection because daily environmental disturbances have gradually restricted further development of such observation on the earth’s surface.After surveying the operational aspects of geo-electrical stations,it is determined that developments in down-hole observation configurations or remote unmanned stations may lessen environmental disturbances when environmental protection is not possible.