Soil is generally simplified as a uniform one-layer model or uniform multi-layer model in present research works, and the influence of soil parameters that may change along the longitudinal direction during seismic responses is usually neglected. With a focus on a practical engineering, a uniform soil-tunnel model and non-uniform soil-tunnel model were established and the internal structural forces and deformations were calculated and compared. The results showed that soil parameters that changed along the longitudinal direction had some influence on internal structural forces and deformation, but the degree of influence was not significant. The reasons were attributed to the small sizes of the tunnels, the small seismic wave amplitude, and the good soil conditions. The results of this study showed that more general seismic response laws should be discussed in future works, based on extensive parameter analyses.