In this study, we took the northern margin fault zone of West Qinling as the study area, which has many hot-spring dew points and severe deformations. We established the fault soil gas profile overlap and conducted field measurement in the cross-fault deformation area to determine the coupling relationship between fault gas segmental characteristics, fault deformation, and seismic activity. We used a variety of methods to evaluate their usefulness in fault earthquake hazard analysis. The results show that there is a good correlation between the geochemical features of soil gas and the distribution of fault deformation characteristics. The comparison results indicate that fault activity is relatively more active in the Wushan segment than in the Weiyuan-Zhangxian segment, and that the Tianshui segment is relatively locked. In addition, due to the active influence of fluid activity, most of the shocks in the Wushan and Gangu strike-slip pull-apart partitions generate medium to small earthquakes. In contrast, strong earthquakes are likely in the west of the Tianshui and Zhangxian segment, and in the Panguchuan region, as the fluid activity and strain rate are weak in these areas. These results can contribute to a theoretical basis for developing a fault gas flow observation network layout with the potential for physical prediction.