On the basis of the wave equation analysis program, the driving process of a large-diameter steel pipe pile in a huge cross-sea bridge project was simulated and analyzed in this paper. The drivability analysis of the pile was performed to determine the performance of a pile-soil-hammer system and the force condition of pile movement during driving and to provide feasible technical parameters for designers and piling contractors. Successful application of wave equation drivability analysis in this project resulted in significant advantages in the design and construction of offshore piles. Various hammers can be used to simulate various piling conditions and obtain a series of parameters such as blow counts, bearing capacity, soil resistance to driving, compressive stress, and tensile stress. The best suited hammer can be chosen using this analysis and a rational installation criterion can be formulated. The total driving time can also be estimated.