Long-span buildings with cylindrical support have poor stability and cannot maintain a stable structural state under strong shock. To solve this problem, this study designs a simulation model for shock analysis of long-span cylindrical support building structures under strong earthquake excitation. Through determining cylindrical analysis rules, analyzing simulations, monitoring finite element support, and performing a bearing capacity analysis of the cylindrical support system, the simulation analysis and monitoring of the model are completed. Consequently, the static analysis of the strong earthquake impact on the long-span building structure is performed, and the structure of the model of a building effected by a strong earthquake is adjusted. Simulation of the strong earthquake impact environment and the experimental results show that the application of analysis and simulation model for large-span cylindrical support building structures effected by a strong earthquake can find the weak points and structural units with poor stability of the long-span cylindrical support structure, thus improving the stability of this kind of buildings effected by of strong earthquakes.