The North Tianshan area is one of the most active areas in the Tianshan Seismic Belt. The investigation of crustal stress state in the area can offer important reliable references to determine the activity and slip tendency of regional faults. The stress data in the North Tianshan area were collected with the hydraulic fracturing and stress relief methods. In this study, the lateral pressure coefficient k, stress accumulative coefficient μ_m, and fault friction coefficient μ were introduced and utilized to analyze the collected stress data. According to Byerlee's law, the analysis results indicate that the regional stress accumulation is high; the faults in the study area are stable, while some local faults tend to slip. The statistics of earthquakes distribution in the study area indicate that small earthquakes are more likely to occur in the central-western and central-eastern areas where the stress is easy to release, while there are few small earthquakes in the northeastern and northwestern areas, where are inferred as locked patch of stress and likely to occur strong earthquakes because the stress accumulation is high. In addition, the statistics show that the fault zone in the study area is more likely to slip along a NWW-SEE orientation.