On July 22, 2013, an M_S6.6 earthquake occurred at the border area between Minxian and Zhangxian Counties, Gansu Province. In this study, 117 groups of three-component acceleration records collected by the Northwestern Strong Motion Networks Center were processed and analyzed, and the resultant instrumental intensity values were calculated and analyzed. The instrumental intensities and the intensities obtained from the Minxian-Zhangxian seismic intensity map (China Earthquake Administration, 2013) were compared and analyzed, and the stations with deviations less than 1 degree were determined to account for 81.8%. The instrumental intensities and the intensities of surveying points within 5 km around the stations were also compared, and the stations with the same intensity account for 50%. The disaster investigation and analysis indicate that most buildings in the Minxian-Zhangxian earthquake-stricken area are of civil and wood structures, and they are more heavily damaged than other regions that experienced the earthquake at the same intensity. Although the instrumental intensity is not quite consistent with the microseismic intensity, the instrumental intensity reflects the earthquake disaster to a certain extent and provides the basis for determining emergency rescue.