To improve the seismic behavior of the panel structures of high-rise buildings, a BIM model for the panel structure instability under continuous vibration is designed in this study. The high-rise building model and structure model are established based on the Revit program, and then a finite element model of high-rise building structure is constructed by the SAP2000 software. An overall structure of the IFOD software of BIM model is designed to realize an intelligent management of BIM model. Based on the BIM model, the wind-induced response of panel structure of high-rise buildings under continuous vibration is analyzed, and the average wind-induced response and fluctuating wind-induced response of panel structure of high-rise buildings are obtained. Therefore, the stability analysis of the panel structures of high-rise buildings under continuous vibration is realized. The experimental results show that the designed BIM model can accurately analyze the acceleration and displacement time history of high-rise buildings under continuous vibration, and compared with traditional methods, the proposed method judges the stability of panel structures under continuous vibration more accurately.