To test the influence of factors such as the lateral stiffness ratio and brace layout forms on the seismic behavior of buckling-restrained braced steel frames with different stories, the seismic performance of three buckling-restrained braced steel frame structures with six, twelve, and eighteen stories were analyzed with the SAP2000 software. The analytical structures have different lateral stiffness ratios with 1, 2, 3, 4, 5 and different brace layout forms with inverted V-shapes and monoclinic directions. The results show that base shear force-roof displacement curves of different buckling-restrained braced steel frame structures present typical bilinear relation. Furthermore, by increasing the lateral stiffness ratio, the story drift ratio of the structure, the roof horizontal displacement, and the shear force of the frame decreased, but the base shear force and the brace axial force increased. The structures with inverted V-shape braces had slightly larger base shear forces and spectral accelerations, but they had smaller roof horizontal displacements, story displacements, interstory shear forces, and shear-sharing ratios of frames than those of the structures with monoclinic layout braces. The analysis generally indicates that the structures with inverted V-shape braces have better seismic performance than the structure with monoclinic layout braces. Lastly, the results show that the lateral stiffness ratio has more significant influence on the seismic behavior of buckling-restrained braced frame structures than the brace layout forms.