To study the anti-progressive collapse performance of base-isolated structures, the static nonlinear and static linear methods are used to analyze the structure of a typical vertical, irregular reinforced concrete foundation using static load method. Based on the anti-progressive collapse mechanism and the demand ability of the backup load path, the anti-progressive collapse performance of the vertical, irregular reinforced concrete base-isolated structure was studied to provide a reference for the anti-progressive collapse design of base-isolated structures. To further study the irregularity of structural arrangements and the influence of the change of podium and tower layers on the progressive collapse of the vertical, irregular isolated structure, the corresponding models were established, and a comparative study was performed. The result shows that except for the corner column, the alternative load path showed a significant catenary mechanism in the Pushover process after the initial failure occurrence of all other columns. When the isolation bearing failed because of the small horizontal stiffness of the isolation layer, adjacent bearings could not provide sufficient lateral constraints to form a catenary mechanism. The ability of the remaining structures to resist progressive collapse can be effectively improved by increasing the structural redundancy and the number of components with alternative load paths. Except the corner column and the corner bearing the initial failure condition, the DCR value of the isolation bearing failure condition is generally larger than the value of the bottom frame failure condition at the corresponding position, and the failure risk of some components in the alternative load path of the isolation bearing failure condition was relatively large.