The demand of earthquake relief materials for different disaster sites can be met by utilizing a mathematical model of earthquake disaster relief based on real-time updating of information to optimize the number of rescue points and delivery time. According to the characteristics of earthquake disaster relief, this paper presents the design and implementation of a mathematical model for earthquake disaster relief that considers time. First, the main factors affecting the demand of earthquake relief materials are analyzed by using the model to forecast the demand, and then the model for calculating the demand for earthquake relief materials is constructed, and the model for grading earthquake relief materials demand based on fuzzy comprehensive evaluation is established. Second, considering time constraint and uncertain demand, the earthquake relief materials are studied and a multi-objective optimization mathematical model of earthquake disaster relief which considers time constraints is constructed. The experimental results show that the model can reduce the delay to reach the disaster site and improve the material demand satisfaction rate while meeting the time constraints.