To study the failure mechanism of single-layer spherical reticulated shell structures under multi-point impact loading, a finite element model of a Kiewitt-6-type single-layer reticulated shell with a 60 m span is established in ANSYS/LS-DYNA. The reticulated shell structure is divided into six sectors along the rib rod and divided into five ring zones along the ring bar; each area has an impact point. The dynamic response and energy transfer rule during the impact process of the reticulated shell structure under the combination of different impact regions are analyzed. Four failure modes of the single-layer spherical reticulated shell structure under multipoint impacts are defined based on the failure and deformation characteristics of the lattice shell structure, and the corresponding failure mechanism of each failure mode is revealed according to the energy transfer characteristics of the entire impact process.