To solve the problems associated with traditional air conditioning and ventilation systems in roadways, i.e., low accuracy of information acquisition, poor performance, and poor environment of anti-seismic roadway, a new air conditioning and ventilation system in anti-seismic roadways has been proposed in this study. First, the overall system architecture was divided into the acquisition layer, the control layer, and the supervision layer. With the main controller as the core, the executive components of the system were accurately judged, and the components were uniformly controlled to complete the hardware design of the system. Subsequently, the information treatment process of the central server was created. The operation instructions of the fan were set, and the environmental information, such as wind speed, was actively collected to obtain the actual loop. The set value and the actual value were compared to determine whether the fan was normally operated. Based on these procedures, the system software functions were developed. The experimental results exhibited that the system can effectively improve the seismic roadway environment when earthquakes of different magnitudes occur; the information acquisition accuracy of this system is as high as 85%, which completely verifies the applicability of the system.