After an earthquake shock, reinforced concrete frame structures feature complex stiffness degradation, and the simulation results are considerably distorted. Therefore, analysis and simulation were performed considering the stiffness degradation law to study the resilience of a reinforced concrete frame structure under earthquake impact. The hysteretic curve of the reinforced concrete frame structure under earthquake was extracted, and different characteristic points were obtained via finite element analysis to form the skeleton curve of restoring force model. According to the skeleton curve and stiffness degradation rule of the restoring force model, the hysteretic curve was constructed to simulate the restoration process of the reinforced concrete frame structure after the earthquake. The restoration experiment simulation results of the reinforced concrete frame structure showed that the story drift was less than 5 mm, and the errors of absolute story acceleration and column bottom lifting were both less than 0.1 mm. The bending moment gap could be closed, and there was no yield phenomenon in the structure, indicating that the simulation results are reasonable.