The traditional methods used to evaluate the anti-collapse reliability of the high-rise building frame structures simply analyze the structures from the overall point of view, resulting in inaccurate results and inaccurate reflection of the collapse resistance of high-rise building frame structures. In this study, a method is proposed to evaluate the anti-collapse reliability of the high-rise building frame structures based on incremental dynamic analysis (IDA). Further, the safety reserve of a high-rise building frame structure is subjected to detailed analysis, and the collapse reserve coefficient of the building frame structure is obtained. The IDA method is used to set the collapse resistance capacity ratio of the high-rise building frame structure, and the anti-collapse reliability of the structure is evaluated according to the coefficient. The test results denote that the evaluation results obtained using the proposed method exhibits considerable reliability and that the collapse resistance of the high-rise building frame structures can be accurately evaluated.