Combined with the seismicity anomalies recorded in the daily tracking word before the Maduo M7.4 earthquake, we systematically sorted out the characteristics of grouping activities of M6 earthquakes in the Qiangtang Block, the low-frequency activities of M5 earthquakes in mainland China, the significant enhancement of moderate seismic activities in the northeastern Tibetan Plateau, and the temporal and spatial anomalies of the seismic swarm activities in the northeastern Tibetan Plateau. We not only summed up the prediction significance of several indexes, but also evaluated the prediction efficiency of some important indexes. Meanwhile, through the temporal and spatial distribution characteristics of Luqu earthquake swarm, we concluded that the Luqu area is a stress-sensitive area; the Luqu earthquake swarm has a good prediction significance for the occurrence of moderate and strong earthquakes in the surrounding area, and should be used as an important index in the subsequent earthquake monitoring process.