Based on the focal mechanisms of 828 M_S ≥ 3.0 earthquakes occurring in the Xinjiang area since 1900, we adopted the method of damped regional-scale stress inversion to obtain the characteristics of regional stress field in Xinjiang. The results revealed that the main types of focal mechanisms in Xinjiang are thrust and strike-slip, and the maximum horizontal principal compressive stress is in nearly SN direction along with local tension and shear. Then, according to the characteristics of regional stress field and spatial distribution of strong earthquakes in the region, we calculated the Coulomb stress changes among strong earthquakes in Tianshan, Kashi-Wuqia, and Kunlun-Altun areas. It is concluded that the strong earthquakes in Tianshan area has little influence on the occurrence of subsequent earthquakes. Kashi-Wuqia area is a strong earthquake prone area, and the epicenters are densely distributed along with obvious earthquake triggering or delay effect. There is little effect between earthquakes in Kunlun-Altun area, except the triggering effect of the Yutian M_S7.3 earthquake in 2008 on the subsequent Yutian M_S7.3 earthquake in 2014. Finally, we also calculated the Coulomb stress changes of surrounding faults caused by strong earthquakes, and the results showed that the Coulomb stress increased along the middle segment of western Boluokenu Fault, the west segment of Kazikearte Fault, the west segment of Muji Fault, and the west segment of Hetian Fault, suggesting the increasing seismic risk.