To study the dynamic response mechanism of large-scale granite earthquake landslides, it is important to develop and prepare granite similar material for shaking table model test. In this paper, iron ore powder, quartz sand, and barite powder were selected as aggregates, gypsum as adjusting material and rosin alcohol solution as binder. The orthogonal test with 4 factors and 5 levels was designed, and the range analysis and multiple linear regression fitting were performed on the test results. On this basis, the influences of various factors on the physical and mechanical properties of granite similar material and the empirical equation of the similar material proportion were obtained. The results show that the density of granite similar material increases with the increase in the ratio of iron powder and barite powder in aggregate. With the increase of binder concentration, the compressive strength, elastic modulus, and cohesion of granite similar material significantly increase. With the increase of gypsum content, the density, compressive strength, and internal friction angle all decrease. The empirical equation of similar material proportion obtained from the test can provide a reference for the preparation of similar granite material or other similar materials.