The combined layout spring foundation structure of a 1 000 MW coal\|fired power plant was selected as the research object, and a finite element model including the foundation structure and the main power house structure was established. Then the seismic time history analysis was carried out on the combined layout type spring foundation structure with the large mass method. According to the analysis results, the optimization algorithm provided by the finite element software ANSYS was adopted in this paper. Taking the size and position of the foundation column as design variables and the seismic response acceleration at the node of turbine bearing center as the objective function, the seismic design of the turbine foundation and the main powerhouse structure were optimized. After optimization, the value of objective function was significantly reduced under varying design variables and the optimization structure can effectively improve the structural seismic performance. The algorithm proposed in this paper breaks through the tradition of only comparing a few solutions for this type of structure, and provides a new idea of optimization.