As the building industry in China gradually transforms and upgrades to intelligent construction, the number of sensors involved in the seismic response and health monitoring technology of high-rise structures, the amount of data to be processed, and the complexity of the system are increasing. In this paper, to meet the intelligent monitoring demand of seismic response and health of high-rise buildings, LoRa spread spectrum communication technology based on the Internet of Things was introduced, and the software and hardware platform scheme of high-rise buildings' seismic response and health monitoring based on LoRa was designed and implemented. The system consisted of multiple LoRa terminal nodes, LoRa gateway, OneNET server, and users. The monitoring data were transmitted through the LoRa network, and the LoRa gateway was connected to the cloud platform through the ESP8266 module to form a visual monitoring interface for the collected monitoring data. The test results show that the packet loss rate of the system within 3 km in an urban open environment is less than 8%. The system can realize the long-distance, low-power, and reliable wireless transmission of seismic response and health monitoring data of high-rise structures, and help users accumulate vibration response data under earthquake, evaluate the state of building structures and manage facilities.