Based on three items of GPS deformation data (2009-2011, 2011-2013, and 2013-2015), the dynamic evolution results of strain field in the eastern section of Northern Tianshan Mountains were calculated using the least square collocation method and the partial derivative relationship between displacement and strain. The current activity characteristics of tectonic area in the eastern section of Northern Tianshan Mountains were re-recognized, and the internal relationship between the spatial distribution characteristics of the strain field and the Hutubi MS6.2 earthquake in 2016 was discussed. The results show that: (1) The temporal change of crustal movement rate and the strength of strain field in the study area show the characteristics of "weak-strong-weak". The principal compressive strain in the N-S direction in the first and third periods is small, about (1~2)×10^-8/a, and that in the second period is significantly enhanced, about (1~6)×10^-8/a. The slip rates in the three periods show that the section of Northern Tianshan Mountains is characterized by dextral strike-slip of "strong [(2.2±0.4) mm/a]-weak (not obvious)-strong [(3.0±1.0) mm/a]", respectively; (2) Earthquakes may be more likely to occur in the center of the four quadrants of the surface strain field' isoline or in the high-density gradient zone of the positive and negative transition zone, which may be the deformation precursor observed by GPS data in the seismogenic process of earthquake; (3) Strong earthquakes are more likely to occur in the high-value area or edge area of shear strain rate (maximum shear strain rate); (4) Compared with the plane strain rate and the maximum shear strain rate, the change of principal strain rate is more suitable for explaining the direction and properties of block movement.