The standardized design method of nuclear power plants is an important means to save the cost of nuclear power construction. It is of great significance to carry out the analysis on the standardized foundation model of nuclear power plants in non rock foundation site. In this paper, based on the investigation data of dynamic parameters of typical sites with soft rock and hard soil at home and abroad, the variation law of dynamic parameters with depth was first summarized. The profile characteristic curves of the foundation shear wave velocity was obtained through normalized analysis, thus determining the preliminary standardized foundation model. Furthermore, the seismic response analysis of the preliminary standard foundation model was carried out using the SuperFLUSH/2D Ver6.0 software. The influence of dynamic parameters on the seismic response was explored by two consideration indexes: the variation of maximum acceleration with depth and the acceleration response spectrum. Finally, according to the similarity and envelope of shear wave velocity profiles of the preliminary foundation model, the standardized foundation model of nuclear power plant in the case of soft rock and hard soil sites was defined, and the reasonable values of corresponding dynamic parameters were given. The model and research results in this paper can provide important references for the standardized design of nuclear power plants in China.