Waste rubber tires are filled with bulk materials to form reinforced earth structures, which have been applied to soil foundations, retaining walls, and guard reinforcement projects, showing an obvious effect on vibration isolation. However, few studies have addressed the liquefaction resistance of tire-reinforced soil. Three groups of small shaking table tests were performed to verify the liquefaction resistance of tire-reinforced sand cushions by changing the drainage conditions of the tire cushion. The results show that tire-reinforced sand cushions have a good liquefaction resistance effect. Compared with a rigid cushion, the differences in the peak excess pore pressure ratio and residual excess pore pressure ratio range between 0.01-0.19 and 0.08-0.16, respectively. The drainage channels provided by tire-reinforced sand cushions inhibit the development of excess pore water pressure and accelerate the dissipation of excess pore water. Pore water is discharged along the interface between the tires and the soil below and the drain channels between the tires. The quantitative index of the soil liquefaction degree is defined by measuring lateral earth pressure, further verifying the liquefaction resistance of tire-reinforced sand cushions. During the vibration process, the tire-reinforced sand cushions have a surface settlement range of 11.3-15.7 mm, showing good deformation coordination performance.