Simplified structural models are primarily adopted for simulation analysis and evaluation to improve the efficiency of urban seismic damage simulation. This study selects typical urban buildings for a comparative analysis of differences in seismic damage simulation results between shear models and flexural-shear models to reduce computational workload in large-scale urban building simulation. A simplified model is adopted to investigate the impacts of three fundamental building attributes—floor area, construction era, and number of stories—on seismic damage simulation and vulnerability assessment results. Buildings are rationally classified according to the influence degree of each factor. Results are as follows: (1) When only damage levels are considered, the results from shear and flexural-shear models are nearly identical. (2) The influence of the three factors on simulation and vulnerability results is in the following order: number of stories ＞ construction era ＞ floor area. (3) Buildings with identical conditions but differing floor areas can be grouped as similar structural types. (4) The influence of the construction era can be disregarded in preliminary seismic damage assessments. Validation results through a regional case confirm that omitting the floor area has no significant impact on the results and even enhances computational efficiency.