To investigate the fundamental characteristics of satellite remote sensing infrared data from different channels and enhance their efficacy in regional strong-earthquake monitoring and prediction, this study systematically compares mid-infrared and thermal infrared channels using moderate resolution imaging spectroradiometer data (2004—2021) from the eastern Qinghai-Xizang Plateau and adjacent regions, focusing on background characteristics and seismic monitoring performance. Results indicate that radiant values from both channels exhibit significant seasonal, latitudinal, and altitudinal characteristics. However, the radiant values from the thermal infrared channel are more significantly influenced by temperature and exhibit larger variation amplitudes. For the annual-scale monitoring of M≥7.0 earthquakes in the mid-eastern Bayan Har block, the mid-infrared channel achieves a superior anomaly correspondence rate (~78%) with zero missing rate (0%), outperforming the thermal infrared channel in seismic application. Therefore, data from the mid-infrared channel are recommended as the primary choice for annual-scale monitoring and forecasting of M≥7.0 earthquakes in this region.