To concentrate plastic deformation in the segments of the structure responsible for dissipating energy while allowing members of the chord in both dissipating and non-dissipating segments to share a common cross-section, a system composed of a prefabricated special truss moment frame with high-strength steel (HSS-PSTMF) has been proposed. The recommended value ranges for key design parameters of HSS-PSTMFs are provided to support engineering applications. To this end, the finite element software ABAQUS was utilized to establish 35 HSS-PSTMF models with varying steel combinations, span-to-height ratios of the energy-dissipating segment, and weld-release restraint ratios. The influences of these parameters on structural bearing capacity, yield mechanism, displacement ductility, and energy dissipation capacity were compared and analyzed. Based on the results, it is recommended that Q460 steel should be prioritized for non-energy-dissipating segments, while Q235 steel should be employed for energy-dissipating segments within the HSS-PSTMF design framework. The optimal range for the span-to-height ratio of the energy-dissipating segment is from 0.67 to 2.33, the length ratio of the energy-dissipating segment to truss beam span is between 0.28 and 0.33, and the weld-free zone measuring 0.6d-0.8d (where d is the chord height) should be maintained at both ends of the chord in the energy-dissipating segment near the gusset plate region.