From 1937 5 M_S ≥ 7.0 earthquakes occured along Eastern Kunlun active Fault Zone:M_S 7.5 Huashixia earthquake in 1937, M_S 7. 1 Dulan earthquake in 1963, M_S 7. 3 Mani earthquake in 1973, M_W 7.5 Mani earthquake in 1997 and M_W 7.8 west to Kunlun Mountain Pass earthquake in 2001. The stress transfer and fault activation among large earthquakes in the fault zone, in northern of Tibet plateau, are studied. The Coulomb stress change on the fault plane of subsequent earthquakes produced by seismic dislocation in elastic half space are calculated. The result shows that Coulomb failure stress on the fault plane is increased by the previous earthquake in every events, it is in favor of occurrence of subsequent events, and the calculation indicates that after west to Kunlun Mountain Pass earthquake (M_W 7.8), the Coulomb failure stress in Xidatan -Dongdatan fault segment is significantly increased up to 0. 006~0. 02 MPa, that imply the probability of seismic hazard in this region increased.