For handling information uncertainty in earthquake prediction, possibility theory and statistics have been the primary method. But in many cases,this method can't produce effective results. For this reason, a new uncertainty method——Evidence theory is introduced in this paper. At first, the representation of uncertainty for earthquake prediction under the frame of this theory is introduced. Then the general procedure of prediction with the D-S combination rule is discussed,and in accordance with the earthquake synthesizing prediction need, the weighted D-S rule is produced.From our study,it is concluded that the method introduced holds its own effectiveness in earthquake prediction.