Tuned liquid damper is a passive energy dissipation device.It is very difficult to grasp the true and accurate characteristics of vibration reduction of tuned liquid damper,because of interaction between water and structure,thus it is becoming an important work to establish a more precise water-structure interaction mode,and discuss the seismic performance of the structure with tuned liquid damper.The fluid-structure interaction（FSI） mode of tuned liquid damper system is built with finite element analysis tool ADINA in this paper.Using the ADNIA FSI module,this fluid-structure interaction mode is calculated by Transient Analysis,simulation results is a good agreement with the test results of the simplified model.By Time history analysis,the instantaneous properties of the flow field of tuned liquid damper are obtained,and then based on this instantaneous properties of the flow field,the relationship between seismic performance of the structure with tuned liquid damper and three factors（frequency ratio,ground motion and mass ratio） is analyzed,the comparative analysis results show that frequency ratio is a most significant influencing factor.At last,some design advices of tuned liquid damper are given.