Traditional analysis method for simulating the transverse vibration response process of high-rise buildings under the influence of a strong earthquake is associated with some problems, such as inaccurate calculation results and longer calculation time. This study aims to propose a new method for simulating the transverse vibration response process of high-rise buildings under strong earthquakes. This method is based on two methods, which are implicit and explicit methods. Both methods can be used to accurately calculate the transverse vibration displacement of high-rise buildings with different degrees of freedom and accurately simulate the deformation process of high-rise buildings during the transverse vibration response. The experimental results show that the proposed method can be applied to calculate the transverse vibration response of high-rise buildings under strong earthquakes with high accuracy and efficiency of operation.