Using the performance-based fragility analysis method, this paper analyzes a base-isolated RC frame-wall structure. This paper selects 20 actual ground motion records with 0.2 g as the step length, adjusts the ground motion parameter PGA, and sets up 140 structure-ground motion sample spaces. The peak inter-story drift ratio of a super structure and the displacement of the isolation layer are then selected as structural performance indices. After dynamic nonlinear time history analysis of each sample, statistics of the structural responses are obtained, and the probability of collapse of the structure beyond each limit damage state is determined. A global reliability method is then used to calculate the collapse reliability indices of the structures and draw them into a base isolation RC frame structural fragility curve. The collapse probability and collapse reliability indices can reflect the performance of base-isolated frame-wall structures and provide a reliable basis for structural earthquake damage assessment.