The dynamic characteristics of near-field earthquakes are different from those of far-field earthquakes; therefore, it is necessary to analyze the seismic performance of structures under near-field ground motion in actual projects. In this paper, a hybrid structure with different vertical stiffnesses of the upper steel structure-lower concrete structure is taken as the research object. The dynamic responses of the structure under the action of near-field pulse-like ground motions, near-field non-pulse-like ground motion, and far-field ground motion are respectively studied. The results show that the near-field pulse-like earthquake will amplify the dynamic response of the story drift ration, interlayer shear force, and acceleration under frequent, designed, and rare earthquakes. Under the rare earthquake, the structural response increases the most. Because the near-field impulse effect will bring unsafe factors to the structure, it is necessary to study the applicability of the hybrid structure with different vertical stiffnesses in the design and construction of layered hybrid frame structures in near fields.