Taking a high-rise steel frame structure building in a 7-degree seismic fortification area as the research object, the seismic technology of high-rise steel frame structure buildings based on isolated-in-place connection technology was studied. Seismic in situ connection technology was used to increase the natural vibration period of the research building by setting elastic skateboard bearings, thick rubber isolation bearings, and viscous dampers in the isolation layer, so as to reduce the influence of earthquakes on the superstructure and enhance seismic performance. Modal and time-history analyses were carried out on the research building. Results showed that the proposed isolation technology only significantly improved the natural vibration period of the structure, but also delayed the formation of torsional vibration mode, significantly reducing the influence of seismic action on the superstructure of the research object. It was shown that the studied technology has a good seismic effect.