After a destructive earthquake, the rapid assessment of earthquake disaster, as the core module of the earthquake emergency command technology system, provides important information services for the earthquake emergency command and decision making of government and emergency management departments at all levels. It is also an important support platform for earthquake emergency rescue and command and decision making. After decades of research in the field of earthquake emergency, the conditions for developing a new generation of rapid assessment system for earthquake disasters have been prepared. In this paper, based on the research foundation of the earthquake intensity attenuation model of different magnitudes, the evaluation model of casualties in different regions, and the design of earthquake emergency thematic map in Gansu Province, a new generation of rapid evaluation prototype system of earthquake disaster in Gansu Province is developed, which can automatically trigger a software, estimate the impact range of earthquake with different magnitudes, calculate the casualties of earthquake disaster personnel in different regions, automatically generate earthquake disaster assessment report, and improve the automation level of the system and the accuracy of calculation results. The software can improve the rapid response ability from an earthquake disaster and can provide more scientific and reliable information services for emergency rescue and command decision making from an earthquake disaster in Gansu Province.