Collapsibility is an important engineering property of loess. In this study, the relationship between collapsibility and physical property indicators is first discussed in the context of the loess microstructure, and then the soil parameters of the collapsible loess in the Luoyang area are obtained on the basis of the Environmental Geological Survey of Central Plains City Group. Fi-nally, the correlation between the collapsibility and physical property indicators of loess is quantitatively analyzed using MATLAB. The results are as follows: (1) Among the physical property parameters related to collapsibility, the loess collapsibility coefficient in the Luoyang area is closely related to the void ratio, dry density, and plasticity index; the degree is in the order of void ratio, dry density, and plasticity index; (2) MATLAB is used to analyze the quantitative relationship between loess collapsibility coefficients and physical property indexes, and the fitting formula of the functional relationship between them in the study area is obtained; (3) Combined with the collapsible mechanism of loess, the rationality of the fitting formula is demonstrated by comparing the measured value with the predicted value. The research method used in this paper also has an enlightening significance for the prediction of the loess collapsibility coefficient in other areas.